Summary: Chondrichthyan (cartilaginous fish) occupies a key phylogenetic position and is important for investigating evolutionary processes of vertebrates.However, limited whole genomes impede our in-depth knowledge of important issues such as chromosome evolution and immunity.Here, we report the chromosome-level genome of white-spotted Market Tote bamboo shark.
Combing it with other shark genomes, we reconstructed 16 ancestral chromosomes of bamboo shark and illustrate a dynamic chromosome rearrangement process.We found that genes on 13 fast-evolving chromosomes can be enriched in immune-related pathways.And two chromosomes contain important genes that can be used Other Chargers to develop single-chain antibodies, which were shown to have high affinity to human disease markers by using enzyme-linked immunosorbent assay.
We also found three bone formation-related genes were lost due to chromosome rearrangements.Our study highlights the importance of chromosome rearrangements, providing resources for understanding of cartilaginous fish diversification and potential application of single-chain antibodies.